Most Children With MIS-C Report Little or No COVID-19 Symptoms: Study

S.Since the COVID-19 pandemic began last year, more than 3,000 children have been diagnosed with multisystem inflammatory syndrome in children, a serious condition associated with coronavirus infection that includes organ dysfunction, low blood pressure, fever and other symptoms, and 36 children died of it.

After analyzing hundreds of cases of MIS-C published in JAMA Pediatrics As of April 6, most patients did not report having had their previous SARS-CoV-2 infection prior to developing the syndrome. Of 1,075 children with MIS-C for whom the authors had information about their battle with COVID-19, only 265 reported a previous illness, and low blood pressure, shock, cardiac dysfunction and ICU admission were among those who did not did more often ‘t.

“This means that pediatricians in primary care must have a high suspicion index because Covid is so widespread in society and children often have an asymptomatic illness as their initial Covid infection,” said Jennifer Blumenthal, a pediatric intensive care doctor and an infectious disease specialist Boston Children’s Hospital, which was not involved in the study, said The New York Times.

Doctors first recognized the association of MIS-C with COVID-19 last spring and noted that patients sometimes had previously mild or asymptomatic cases of the infection. “You had the infection, you got over it. And suddenly . . . A few weeks later you can have this breakdown in your body, ”described Alvaro Moreira, a neonatologist at the University of Texas Health in San Antonio The scientist in September.

In the latest study, doctors from US health authorities examined 1,733 reports of MIS-C. Diagnoses peaked in early May, early August, and December after peaking for two to five weeks in COVID-19 cases.

Patients often had fever, abdominal pain, vomiting, rash, diarrhea, and conjunctival hyperemia when the blood vessels in the eye appear red and dilated. Half of the children had low blood pressure and almost a third developed heart complications. Around 58 percent were admitted to the intensive care unit, and 24 patients in the study died.

Another study published last month found that approximately 10 percent of children hospitalized with MIS-C had an acute kidney injury.

It is not clear why some children develop MIS-C. The authors write in their paper: “It is assumed that most MIS-C diseases are due to asymptomatic or mild COVID-19, with hyperinflammation coinciding with the highest antibody production a few weeks after the first SARS-CoV-2 infection . ” A study last year found that children with MIS-C are immunologically different from adults with severe COVID-19. In particular, the adults had higher levels of certain cytokines that were involved in fighting infections.

The risk of developing MIS-C remains very low for children. According to the American Academy of Pediatrics (AAP), 3.47 million children tested positive for COVID-19 this month. Sean O’Leary, vice chairman of the AAP’s Infectious Diseases Committee, tells the Associated Press that most children “respond very well to treatment and the vast majority get completely better”.



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