Wolbachia-Infected Mosquitoes Spread of Stymie Dengue: Study

D.Distributing mosquito eggs infected with Wolbachia Bacteria resulted in a dramatic decrease in dengue cases and hospitalizations in areas where the intervention was not compared to where the intervention was not, researchers report in today (June 10) The New England Journal of Medicine. While researching too Wolbachia Given that a potential public health tool to combat dengue is more than a decade old, this is the strategy’s first randomized trial.

“This is the gold standard for proving that Wolbachia is a highly effective intervention against dengue, ”says Oliver Brady, a dengue expert at the London School of Hygiene and Tropical Medicine who was not involved in the study The Atlantic. “It has the potential to revolutionize mosquito control.”

Wolbachia is found in numerous species of arthropod, where it manipulates reproduction in its hosts to ensure that it spreads throughout the population. Laboratory experiments showed that once in mosquitoes, Wolbachia competes for resources with the virus that causes dengue and prevents the virus from establishing itself in the host. (This principle also applies to other viruses, such as Zika.)

Wolbachia is not naturally present in the dengue vector Aedis Egypt, So more than a decade ago, the researchers developed a method of introducing the bacteria into mosquitoes in such a way that they can be passed on from the females to their offspring. Then to see if Wolbachia Fight dengue fever in the real world, researchers from the non-profit World Mosquito Program (WMP) have published A. aegypti infected with the bacterium in Northern Australia and several other countries in 2011. The number of dengue infections in the Australian release area decreased by 96 percent after the introduction and the results from the other sites were also encouraging, but the work was observational and couldn’t definitely prove that the Wolbachia which caused the cuts.

In the current study, the WMP randomly assigned 24 geographic areas in the city of Yogyakarta, Indonesia, either to receive infected mosquito eggs or to serve as controls. The researchers included participants with a fever who went to clinics in the treated and untreated areas, and found that 9.4 percent of people in the control areas had dengue fever, while only 2.3 percent of people with a fever who lived in Lived in the egg release zones, suffered from dengue disease. The researchers reported that 77 percent reduction in dengue incidence in a press release last year. In the new paper, they also report an 86 percent decrease in hospital admissions for dengue in the treated areas.

“This is really the big deal,” says Cameron Simmons, co-author of the study from Monash University in Melbourne and the WMP science. “It’s the weight of the hospital stay. . . that really expands the health systems. ”

According to The Atlantic, the WMP now operates in 11 countries with 7 million people in territories serving Wolbachia-infected A. aegypti. The organization aims to protect at least 500 million people by 2030.

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